Is the herbal supplement NT (Number Ten) effective in treating obesity?
From: International Journal of Obesity
- Greenway, F.L., Liu, Z., Martin, C.K., Kai-yuan, W., Nofziger, J., Rood, J.C., Yu, Y., Amen, R.J., 2006. Safety and efficacy of NT, an herbal supplement, in treating human obesity. International Journal of Obesity 30, 1737–1741.
- 24 healthy women
- Participants were randomised to four groups of six: (1) oral freeze-dried NT 6 gm/day, (2) bed-dried NT 6 gm/day, (3) freeze-dried NT 12 gm/day or (4) placebo.
- Number Ten dose was escalated over 3 weeks and maintained for 8 weeks on a 700 kcal/day diet below maintenance.
- Food intake was measured at commencement and at 4 weeks.
- Weight loss was 1.8 kg for placebo and 0.4 kg for 500 mg NT, whereas the 250 mg bed- and freeze-dried NT gained 0.43 and 0.87 kg, respectively.
- The food intake increased 74 kcal with 250 mg freeze-dried NT and decreased 193.7 kcal with 500 mg freeze-dried NT.
- Number Ten is not be an effective dietary herbal supplement for the treatment of obesity owing to dose-limiting gastrointestinal toxicity.
- No (without confidence)
- Number Ten was found to contain sennosides, known laxatives and gallic acid, which is known to give weight loss in rodents. The results suggest that this does not translate to humans.
- The study was weak and participant numbers were small. Furthermore, not all participants would be considered obese, merely overweight.