Is Tramadol effective and safe in patients with Osteoarthritis?
From: The Cochrane Collaboration
- Cepeda, M., Camargo, F., Valencia, L., Zea, C., 1996. Tramadol for osteoarthritis, in: The Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd.
- 11 trials with 1,109 participants
- The paper is a systematic review / meta analysis of all relevant trials.
- This means that the data from all similar trials has been grouped to form an overall outcome.
- Participants who received tramadol had 12% less pain than patients who received placebo.
- Participants who received tramadol had a 37% increase in the likelihood of reporting moderate improvement
- Participants who received tramadol had 2.27 times the risk of developing minor adverse events and 2.6 times the risk of developing major adverse events, compared to participants who received placebo.
- Tramadol taken for up to three months may decrease pain, may improve stiffness and function and overall-well being.
- Tramadol may cause side effects such as nausea, vomiting, dizziness, constipation, tiredness, and headache.
- Yes (with confidence) – in comparison to a placebo