Is Tramadol effective and safe in patients with Osteoarthritis?

From: The Cochrane Collaboration

Journal rating:
rating: 98%
Study Quality:
rating: 100%
%

Overall Reliability

Article Quality:
rating: 75%
Partcipants
rating: 50%

Participants/situation

  • 11 trials with 1,109 participants

Study

  • The paper is a systematic review / meta analysis of all relevant trials.
  • This means that the data from all similar trials has been grouped to form an overall outcome.

Results

  • Participants who received tramadol had 12% less pain than patients who received placebo.
  • Participants who received tramadol had a 37% increase in the likelihood of reporting moderate improvement
  • Participants who received tramadol had 2.27 times the risk of developing minor adverse events and 2.6 times the risk of developing major adverse events, compared to participants who received placebo.
  • Tramadol taken for up to three months may decrease pain, may improve stiffness and function and overall-well being.
  • Tramadol may cause side effects such as nausea, vomiting, dizziness, constipation, tiredness, and headache.

Answer

  • Yes (with confidence) – in comparison to a placebo

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