Is St. John's wort an effective treatment for depression?

From: The Cochrane Collaboration

Journal rating:
rating: 98%
Study Quality:
rating: 100%
%

Overall Reliability

Article Quality:
rating: 50%
Partcipants
rating: 50%

Participants/situation

  • 29 trials including 5,489 patients

Study

  • The paper is a systematic review / meta analysis of all relevant trials.
  • This means that the data from all similar trials have been grouped to form an overall outcome.
  • The authors compared treatment with extracts of St. John’s wort for 4 to 12 weeks with placebo treatment or standard antidepressants.

Results

  • The results suggest that;
  • St John's wort is superior to placebo in patients with major depression;
  • St John's wort is similarly effective as standard antidepressants; and
  • St John's wort has fewer side effects than standard antidepressants. 

Answer

  • Yes (with confidence)

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