Does the fibre complex, Litramine, reduce body weight in the overweight and obese?
- Grube, B., Chong, P.-W., Lau, K.-Z., Orzechowski, H.-D., 2013. A natural fiber complex reduces body weight in the overweight and obese: A double-blind, randomized, placebo-controlled study. Obesity 21, 58–64.
- 125 overweight and obese adults
- Subjects were advised on physical activity, and received nutritional counselling, including low calorie diet plans (30% energy from fat and 500 kcal deficit/day).
- After a 2-week placebo phase, subjects received either 3 g/day of Litramine or a placebo.
- At the end of week 12, weight loss in the Litramine group was significantly higher when compared to the placebo group (4.5% (3.8 kg) vs. 1.8% (1.4 kg); difference 2.4 kg).
- Litramine also showed significantly more reduction in average BMI in comparison to the placebo group (1.3 kg/m2 vs. 0.5 kg/m2)
- Waist circumference in the Litramine group was significantly decreased compared with the placebo group.
- There was 1.4 kg or 0.8% difference in body fat mass between Litramine and placebo groups at the end of the 12-week study.
- No adverse reactions reported from those taking Litramine
- Yes (with confidence)
- Results are to be taken with caution where a conflict of interest is applicable; several of authors work for InQpharm who manufacture Litramine.