Does the fibre complex, Litramine, reduce body weight in the overweight and obese?

From: Obesity

Journal rating:
rating: 97%
Study Quality:
rating: 85%

Overall Reliability

Article Quality:
rating: 75%
rating: 25%


  • 125 overweight and obese adults


  • Subjects were advised on physical activity, and received nutritional counselling, including low calorie diet plans (30% energy from fat and 500 kcal deficit/day).
  • After a 2-week placebo phase, subjects received either 3 g/day of Litramine or a placebo. 


  • At the end of week 12, weight loss in the Litramine group was significantly higher when compared to the placebo group (4.5% (3.8 kg) vs. 1.8% (1.4 kg); difference 2.4 kg).
  • Litramine also showed significantly more reduction in average BMI in comparison to the placebo group (1.3 kg/m2 vs. 0.5 kg/m2)
  • Waist circumference in the Litramine group was significantly decreased compared with the placebo group.
  • There was 1.4 kg or 0.8% difference in body fat mass between Litramine and placebo groups at the end of the 12-week study.
  • No adverse reactions reported from those taking Litramine


  • Yes (with confidence)


Editors Notes

  • Results are to be taken with caution where a conflict of interest is applicable; several of authors work for InQpharm who manufacture Litramine.