Does phytosterol have a beneficial effect on cholesterol metabolism?
From: The American Journal of Clinical Nutrition
- Racette, S.B., Lin, X., Lefevre, M., Spearie, C.A., Most, M.M., Ma, L., Ostlund, R.E., Jr, 2010. Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am. J. Clin. Nutr. 91, 32–38.
- 18 adults
- Participants received a phytosterol-deficient diet plus beverages supplemented with 0, 400, or 2000 mg phytosterols/day for 4 wk each (in random order).
- All meals were prepared in a metabolic kitchen; breakfast and dinner on weekdays were eaten on site.
- Phytosterol intakes (diet plus supplements) averaged 59, 459, and 2059 mg/d during the 3 diet periods.
- Relative to the 59-mg diet, the 459- and 2059-mg phytosterol intakes significantly increased total faecal cholesterol excretion and biliary cholesterol excretion and reduced percentage intestinal cholesterol absorption.
- Serum LDL cholesterol declined significantly only with the highest phytosterol dose; a trend was observed with the 459-mg/d dose
- Yes (with confidence) – at doses of 459- and 2059-mg phytosterol.
- Phytosterol supplementation of 2 g/d is recommended by the National Cholesterol Education Program to reduce 'bad' LDL cholesterol.
- Because it is not feasible to obtain 2 g phytosterols in a natural diet, food manufacturers enrich common products (eg, margarine, orange juice, yogurt drinks, and granola bars) with phytosterols to enable individuals to achieve the recommended intake goal.
- A large failing with the study is the low level of participants, and as such, the results are to be treated with caution.