Does diet influence glycaemic control and risk factors for cardiovascular disease in patients with type 2 diabetes who are hyperglycaemic?
- Coppell, K.J., Kataoka, M., Williams, S.M., Chisholm, A.W., Vorgers, S.M., Mann, J.I., 2010. Nutritional intervention in patients with type 2 diabetes who are hyperglycaemic despite optimised drug treatment--Lifestyle Over and Above Drugs in Diabetes (LOADD) study: randomised controlled trial. BMJ 341, c3337–c3337.
- 93 participants
- Participants were aged less than 70 years with type 2 diabetes and a glycated haemoglobin (HbA1c) of more than 7% despite optimised drug treatments plus at least two of overweight or obesity, hypertension, and dyslipidaemia.
- Intensive individualised dietary advice (according to the nutritional recommendations of the European Association for the Study of Diabetes) for six months; both the intervention and control participants continued with their usual medical surveillance.
- The difference in HbA1c between the intervention and control groups at six months was highly statistically significant, as were the decreases in weight, body mass index, and waist circumference. A decrease in saturated fat and an increase in protein in the intervention group were the most striking differences in nutritional intake between the two groups.
- The intervention found that intensive dietary advice has the potential to appreciably improve glycaemic control and anthropometric measures in patients with type 2 diabetes and unsatisfactory HbA1c despite optimised hypoglycaemic drug treatment.
- Yes (with confidence)
- This effect of the intervention occurred despite the fact that some of the patients considered to be on maximum drug treatment were able to reduce their dose of tablets or insulin.