Does diabetes increase the risk of a range of vascular diseases?
From: The Lancet
- The Emerging Risk Factors Collabo, 2010. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. The Lancet 375, 2215–2222.
- 698,782 people from 102 studies
The paper is a systematic review / meta analysis of all relevant trials.
This means that the data from all similar trials has been grouped to form an overall outcome.
- Patients with diabetes were;
- twice as likely to suffer from coronary heart disease;
- 2.27 times as likely to suffer anischaemic stroke;
- 1.56 times as likely to suffer an haemorrhagic stroke;
- 1.84 times as likely to suffer an unclassified stroke;
- and 1.73 times as likely to suffer an aggregate of other vascular deaths.
- Risk of coronary heart disease was higher in women than in men, at 40—59 years than at 70 years and older, and with fatal than with non-fatal disease.
- Fasting blood glucose concentration was non-linearly related to vascular risk, with no significant associations between 3·90 mmol/L and 5·59 mmol/L.
- Compared with fasting blood glucose concentrations of 3·90—5·59 mmol/L, risk of coronary heart disease was increased 7% for lower than 3·90 mmol/L; 11% for 5·60—6·09 mmol/L; and 17% for 6·10—6·99 mmol/L
- Yes (with confidence)