Does caffeine during pregnancy increase the risk of miscarriage?
From: The American College of Obstetricians and Gynecologists
- Weng, X., Odouli, R., Li, D.-K., 2008. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. American Journal of Obstetrics and Gynecology 198, 279.e1–279.e8.
- 1,063 women.
- Information on exposure to caffeine consumption during pregnancy was obtained during an in-person interview conducted soon after a woman’s pregnancy was confirmed.
- Pregnancy outcomes up to 20 weeks of gestation were determined searching medical records and contacting participants whose outcomes could not be determined.
- Overall 172 of women (16.18%) miscarried.
- Compared with nonusers, women who consumed 0-200 mg caffeine daily had an increased risk of miscarriage (15% vs 12%), and the corresponding risk was much greater (25%) among women who consumed more than 200 mg caffeine daily.
- After adjustment for potential confounders including maternal age, race, education, household income, marital status, previous miscarriage, smoking, alcohol consumption, Jacuzzi use, and nausea and vomiting, the increased risk of miscarriage was 42% and 123% for daily caffeine consumption of 0-200 mg and 200 mg or more, respectively.
- Caffeine intake of 200 mg or greater remained associated with an increased risk of miscarriage, regardless of whether a woman changed her pattern of caffeine intake after pregnancy
- Yes (with confidence)