Does Omega-3 Fatty Acid Levels have a positive effect on Telomeric Aging in Patients With Coronary Heart Disease?
- Farzaneh-Far, R., Lin, J., Epel, E.S., Harris, W.S., Blackburn, E.H., Whooley, M.A., 2010. Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA 303, 250–257.
- 608 outpatients
The investigators measured leukocyte telomere length at baseline and again after 5 years.
- Models were used to investigate the association of omega-3 fatty acids with subsequent change in telomere length.
- Individuals in the lowest quartile of omega-3 experienced the fastest rate of telomere shortening, whereas those in the highest quartile experienced the slowest rate of telomere shortening.
- Among the patients with coronary artery disease, there was a relationship between the higher levels of omega-3 fatty acids and the slower rate of telomere shortening over 5 years.
- Yes (with confidence)
- A teleomere is a region of your DNA. As a cell begins to become cancerous, it divides more often and its telomeres become very short. If its telomeres get too short, the cell may die.
- Studies have found shortened telomeres in many cancers, including pancreatic, bone, prostate, bladder, lung, kidney, and head and neck. In addition, people with many types of cancer have been found to possess shorter leukocyte telomeres than healthy controls.