Does Metformin reduce the risk of early pregnancy loss in women with polycystic ovary syndrome?

From: The Journal of Clinical Endocrinology & Metabolism

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  • 96 pregnant women with polycystic ovary syndrome.


  • All participants who had became pregnant between 1996 and 2000 were examined who either did not receive metformin at the time of conception, or during pregnancy (control group = 31 participants), or became pregnant while taking metformin and continued taking metformin at a dose of 1000–2000 mg daily throughout pregnancy (metformin group = 65 partcipants). 


  • The rate of early pregnancy loss in the metformin group was 8.8% (6 of 68 pregnancies), as compared with 41.9% (13 of 31 pregnancies) in the control group.
  • In the subset of women in each group with a prior history of miscarriage, the rate of early pregnancy loss was 11.1% (4 of 36 pregnancies) in the metformin group, as compared with 58.3% (7 of 12 pregnancies) in the control group.
  • The authors conclude that Metformin administration during pregnancy reduces first- trimester pregnancy loss in women with the polycystic ovary syndrome.


  • Yes (with confidence)


Editors Notes

  • Polycystic ovary syndrome is the most common form of female infertility in the United States, and it affects 5–10% of women of reproductive age.
  • In addition to difficulty conceiving, women with polycystic ovary syndrome are at increased risk of miscarriage after either spontaneous or assisted conception.
  • Rates of early pregnancy loss, defined as miscarriage during the first trimester, are reported to be 30 –50% in women with polycystic ovaries or the polycystic ovary syndrome, which is 3-fold higher than the rate of 10–15% reported in retrospective studies for normal women