Do calcium supplements increase the risk of cardiovascular events?
- Bolland, M.J., Avenell, A., Baron, J.A., Grey, A., MacLennan, G.S., Gamble, G.D., Reid, I.R., 2010. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 341, c3691–c3691.
- 15 trials including 20,072 participants
- The paper is a systematic review / meta analysis of all relevant trials.
- This means that the data from all similar trials has been grouped to form an overall outcome.
- Participants were prescribed calcium supplements (≥500 mg/day) for more than one year.
- 309 people allocated to calcium had a heart attack compared with 241 allocated to placebo.
- Calcium supplements are associated with an increased risk of a heart attack.
- Yes (with confidence)
- Given the modest benefits of calcium supplements on bone density and fracture prevention, a reassessment of the role of calcium supplements in the management of osteoporosis is needed.