Do calcium supplements increase the risk of cardiovascular events?

From: BMJ

Journal rating:
rating: 99%
Study Quality:
rating: 100%
%

Overall Reliability

Article Quality:
rating: 65%
Partcipants
rating: 75%

Participants/situation

  • 15 trials including 20,072 participants

Study

  • The paper is a systematic review / meta analysis of all relevant trials.
  • This means that the data from all similar trials has been grouped to form an overall outcome.

Results

  • Participants were prescribed calcium supplements (≥500 mg/day) for more than one year.
  • 309 people allocated to calcium had a heart attack compared with 241 allocated to placebo.
  • Calcium supplements are associated with an increased risk of a heart attack.

Answer

  • Yes (with confidence)

i

Editors Notes

  • Given the modest benefits of calcium supplements on bone density and fracture prevention, a reassessment of the role of calcium supplements in the management of osteoporosis is needed.

Keywords