Can we determine the most effective antibiotics for treating pneumonia in children?

From: The Cochrane Collaboration

Journal rating:
rating: 98%
Study Quality:
rating: 100%
%

Overall Reliability

Article Quality:
rating: 65%
Partcipants
rating: 75%

Participants/situation

  • 27 studies including 11,928 children

Study

  • The paper is a systematic review / meta analysis of all relevant trials.
  • This means that the data from all similar trials has been grouped to form an overall outcome.

Results

  • For outpatient treatment of pneumonia, amoxycillin is an alternative treatment to co-trimoxazole.
  • Oral amoxycillin in hospitalised children with severe pneumonia without hypoxia (decreased level of oxygen) may be effective.
  • For very severe pneumonia, a combination of penicillin or ampicillin and gentamycin is more effective than chloramphenicol alone.

Answer

  • Yes (with confidence)

i

Editors Notes

  • Pneumonia is the leading cause of mortality in children under five years of age. Most cases of community-acquired pneumonia in low-income countries are caused by bacteria. 

Keywords