Can we determine the most effective antibiotics for treating pneumonia in children?

From: The Cochrane Collaboration

Journal rating:
rating: 98%
Study Quality:
rating: 100%

Overall Reliability

Article Quality:
rating: 65%
rating: 75%


  • 27 studies including 11,928 children


  • The paper is a systematic review / meta analysis of all relevant trials.
  • This means that the data from all similar trials has been grouped to form an overall outcome.


  • For outpatient treatment of pneumonia, amoxycillin is an alternative treatment to co-trimoxazole.
  • Oral amoxycillin in hospitalised children with severe pneumonia without hypoxia (decreased level of oxygen) may be effective.
  • For very severe pneumonia, a combination of penicillin or ampicillin and gentamycin is more effective than chloramphenicol alone.


  • Yes (with confidence)


Editors Notes

  • Pneumonia is the leading cause of mortality in children under five years of age. Most cases of community-acquired pneumonia in low-income countries are caused by bacteria.