Are statins beneficial in people with no history of cardiovascular disease (including heart attack, angina and stroke)?

From: The Cochrane Collaboration

Journal rating:
rating: 98%
Study Quality:
rating: 100%

Overall Reliability

Article Quality:
rating: 75%
rating: 75%


  • 19 trials including 56,934 patients


  • The paper is a systematic review / meta analysis of all relevant trials.
  • This means that the data from all similar trials has been grouped to form an overall outcome.


  • Likelihood of premature death from all causes was reduced by 14% by those taking statins.
  • Revascularisation (the restoration of an adequate blood supply to the heart) by means of surgery (coronary artery bypass graft ) or by angioplasty was also reduced in those taking statins.
  • Levels of 'bad' LDL cholesterol was reduced in all trials.
  • There was no evidence of any serious side effects from statin prescription.


  • Yes (with confidence)


Editors Notes

  • Cardiovascular disease, which comprises heart attacks (myocardial infarction), angina and strokes, is ranked as the number one cause of mortality and is a major cause of morbidity world wide.