Are statins beneficial in people with no history of cardiovascular disease (including heart attack, angina and stroke)?
From: The Cochrane Collaboration
- Taylor, F., Huffman, M.D., Macedo, A.F., Moore, T.H., Burke, M., Davey Smith, G., Ward, K., Ebrahim, S., 1996. Statins for the primary prevention of cardiovascular disease, in: Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd.
- 19 trials including 56,934 patients
- The paper is a systematic review / meta analysis of all relevant trials.
- This means that the data from all similar trials has been grouped to form an overall outcome.
- Likelihood of premature death from all causes was reduced by 14% by those taking statins.
- Revascularisation (the restoration of an adequate blood supply to the heart) by means of surgery (coronary artery bypass graft ) or by angioplasty was also reduced in those taking statins.
- Levels of 'bad' LDL cholesterol was reduced in all trials.
- There was no evidence of any serious side effects from statin prescription.
- Yes (with confidence)
- Cardiovascular disease, which comprises heart attacks (myocardial infarction), angina and strokes, is ranked as the number one cause of mortality and is a major cause of morbidity world wide.