Are opioids more effective on pain and function in patients with osteoarthritis of the hip or knee in comparison to a placebo?
From: The Cochrane Collaboration
- Nüesch, E., Rutjes, A.W., Husni, E., Welch, V., Jüni, P., 1996. Oral or transdermal opioids for osteoarthritis of the knee or hip, in: Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd.
- Ten trials with 2,268 participants included.
- The paper is a systematic review / meta analysis of all relevant trials.
- This means that the data from all similar trials has been grouped to form an overall outcome.
- 35% of people who use opioids experience a reduction in pain
- 31% of people who use placebo experience a reduction in pain
- 29% of people who use opioids experience an improvement in physical function
- 26% of people who use placebo experience an improvement in physical function.
- 23% of people who used opioids experienced side effects
- 15% of people who used a placebo experienced side effects
- Yes (without confidence); albeit the authors have not recommended routine use of non-tramadol opioids due to their adverse effects.
- Opioids are powerful pain-relieving substances that are used for the pain of cancer or osteoarthritis.