Are corticosteroid injections for osteoarthritis of the knee effective?
- Arroll, B., 2004. Corticosteroid injections for osteoarthritis of the knee: meta-analysis. BMJ 328, 869–0.
- 10 studies including 494 participants
- The paper is a systematic review / meta analysis of all relevant trials.
- This means that the data from all similar trials has been grouped to form an overall outcome.
- Evidence supports a two week improvement in symptoms of osteoarthritis of the knee after intra-articular corticosteroid injection.
- Improvement was also shown in the only methodologically sound studies addressing longer term response (16-24 weeks).
- A dose equivalent to 50 mg of prednisone may be needed to show benefit at 16-24 weeks.
- Yes (with confidence) – over the short-term only.
- Osteoarthritis is the single most common cause of disability in older adults, with 10% of patients aged 55 or more having painful disabling osteoarthritis of the knee, a quarter of whom are severely disabled.